Applications

Pharma / LNP

Microfluidic lipid nanoparticle formulation for mRNA with an open architecture — no single-use cartridge lock-in.

Pharma / LNP
40–200 nm
Controlled LNP size, PDI < 0.2 in typical regimes
Open architecture
Platform with no proprietary lock-in
1 day
Time to first result
Problem

mRNA therapeutics and vaccines require lipid nanoparticles with precise size control (40–200 nm) and a narrow size distribution. The platforms that dominate the market lock you into proprietary single-use cartridges at $500–2,000 per run, and at scale it is the consumables that drive the development budget. On top of that, Western LNP formulation platforms are unavailable in Russia under sanctions.

Solution

The LABADVANCE Workstation with a dedicated LNP mixer chip formulates nanoparticles with a controlled size distribution through reusable microfluidic mixing. The open architecture means no cartridge lock-in and no DRM: the chip is cleaned, disassembled and reused. Size is set by flow rates and mixing geometry, delivering PDI < 0.2 in typical operating regimes.

Result

A domestically produced LNP formulation platform for developers of mRNA therapeutics, gene-therapy vectors and nucleic acid delivery systems. A single mixing principle scales from screening (µL/min) to pilot (mL/min) via numbering-up, with no re-optimization. Comparable performance at a fraction of the per-run cost of imported systems.

Capabilities

What you can do.

mRNA-LNP formulation with controlled size (typically 60–100 nm) and high encapsulation efficiency
Screening of lipid compositions, N/P ratios and flow regimes on a single chip
LNPs for delivery of siRNA, ASO and CRISPR-Cas9 — gene-therapy vectors
Liposomes, solid lipid nanoparticles and lipid-polymer hybrids with control over size and lamellarity
Quality control: size distribution and PDI (DLS), encapsulation efficiency assessment
Reusable mixer chips and standard fittings — no proprietary consumables
Interested in microfluidic technology?

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